#Trade Shows & Events
Biophysical and stability characterization of antibody-drug conjugates
Live Webinar September 13th, 2018
Antibody-Drug Conjugates (ADCs) are a rapidly growing class of oncology therapeutics wherein a potent cytotoxic drug is conjugated to the antibody molecule. The impact of drug conjugation on the antibody's conformation needs to be evaluated. Additionally, the drug conjugation can also affect various physical properties of the antibody molecule which in turn can affect its stability and aggregation propensity. This presentation summarizes results from our study on aggregation of a lysine-conjugated ADC and its unconjugated mAb under accelerated heat and agitation stresses. Additionally, we also highlight spectroscopic and DSC based analytical approaches that can be used to detect subtle differences between the ADC and mAb.
Who should attend?
• Anyone interested in biopharmaceuticals, especially antibody-based therapeutics
What will you learn?
• The biophysical properties of ADCs, some analytical considerations for ADCs, and the impact of drug conjugation on protein aggregation
You can register for free to all our webinars and you will automatically receive the On Demand version