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Biophysical and stability characterization of antibody-drug conjugates

Live Webinar September 13th, 2018

Antibody-Drug Conjugates (ADCs) are a rapidly growing class of oncology therapeutics wherein a potent cytotoxic drug is conjugated to the antibody molecule. The impact of drug conjugation on the antibody's conformation needs to be evaluated. Additionally, the drug conjugation can also affect various physical properties of the antibody molecule which in turn can affect its stability and aggregation propensity. This presentation summarizes results from our study on aggregation of a lysine-conjugated ADC and its unconjugated mAb under accelerated heat and agitation stresses. Additionally, we also highlight spectroscopic and DSC based analytical approaches that can be used to detect subtle differences between the ADC and mAb.

Who should attend?

• Anyone interested in biopharmaceuticals, especially antibody-based therapeutics

What will you learn?

• The biophysical properties of ADCs, some analytical considerations for ADCs, and the impact of drug conjugation on protein aggregation

You can register for free to all our webinars and you will automatically receive the On Demand version

Details

  • Malvern WR14 1XZ, UK
  • Malvern Panalytical