This paper discusses the impact of various technological innovations used in the Contact Shock Freezers by B Medical Systems to preserve the quality of plasma, especially the coagulation factors.
Human plasma is an important transfusion component and also functions as a raw material for the manufacturing of coagulation factor concentrates, but at the same time is expensive and supplies are limited. The freezing process is an important step that may result in loss of activity if it is not handled optimally. Even when using the contact shock freezers, there could be a deviation in the freezing time and irregular freezing of plasma bags due to the presence of air pockets that can act as an insulation layer, or the irregular size of the plasma bags, which prevent optimized contact of the freezer plates.
Inclining the freezing plates of the contact shock freezer to 5° can lead to an average absolute increase of percentage contact area without air by 19%. For bigger air pockets (like 50ml), inclining the plates at 5° can lead to an actual increase of surface area without air contact by 145% for a 350ml bag. This along with the silent acting linear actuators, which can move anti-parallel up to 10mm, can help in the rapid and homogeneous freezing of plasma that can have a strong positive impact on the quality of the plasma.