Two papers on SIS hydrogel published in the SCI core journals for SIS bioligical material

The news of 6 papers on SCI core journals in 2021 is still fresh, here comes another big news for Biosis Healing in the beginning of 2022.

Picture: The research result of Biosis Healing SIS hydrogel included in the authoritative SCI core journal "Materials Today Bio", with an impact factor of 7.348

Recently, two papers on the latest research results of Biosis Healing SIS hydrogels have been included in the full text of the international top journal "Materials Today Bio" in the field of materials and "Cell Proliferation", a Q1 journal of cell biology, with impact factors of 7.348 and 6.831 respectively.

This two studies are completed by the team of Prof. Zhao Bo, Dr. Wei Pengfei and Dr. Jing Wei from Biosis Healing, the team of Prof. Deng Jiayin and Dr. Liu Zihao from School and Hospital of Stomatology Tianjin Medical University, and the team of Dr. Ma Shiqing from the Second Hospital of Tianjin Medical University.

SIS biomaterials are derived from animal small intestinal submucosa, mainly natural ECM, including type I, type III collagen and various biologically active factors. Collagen molecules in SIS can self-assemble and condense into three-dimensional (3D) network hydrogels under 37℃, namely SIS hydrogels. Because the structure and bioactivity of SIS hydrogels can be fine-tuned for desired applications, they are widely used to promote regeneration of damaged tissues.

This two studies are based on the advantages of SIS hydrogels, aiming at the pain points and difficulties in the field of clinical bone repair and diabetic foot wound healing, and exploring their potential applications, providing a reliable theoretical basis for the clinical application of SIS hydrogels in this field.

Introduction:

Bone defects are often caused by trauma, infection, tumors, congenital diseases, and can lead to functional impairments derived from skeletal disease. Compared with bone grafting, bone tissue engineering techniques have been considered as a potential treatment for bone reconstruction. Thermosensitive hydrogels can mimic the extracellular matrix (ECM) environment and can be widely used as scaffolds for bone tissue engineering.

Injectable thermosensitive hydrogels composed of small intestinal submucosa (SIS) and exosomes derived from bone marrow mesenchymal stem cells (BMSC) can be used for bone regeneration.

In this study, SIS hydrogel was added to exosomes and fusion peptides, and in vitro experiments showed that fusion peptides helped to promote the positive effect of exosomes on the osteogenic differentiation of BMSCs. At the same time, the results of hydrogels combined with exosomes and fusion peptides in the treatment of rat calvarial defect models showed that fusion peptides could increase the remaining amount and stability of exosomes, thereby enhancing the therapeutic effect on calvarial defects.

Therefore, the study proves that SIS hydrogels with CA modified by fusion peptides and exosomes can be applied in bone regenerative medicine.