Fibrinogen Reagent Kit (FIB)

coagulation, hemostasis and thrombosis

Fibrinogen(FIB) is the precursor of fibrin. In the final stage of coagulation, soluble fibrinogen is converted into insoluble fibrin, which causes blood to coagulate. Determination of plasma fibrinogen helps to understand the state of coagulation function.

Normal value

Biuret colorimetry: 2-4g/L (200-400mg/dl).　Rocket electrophoresis: 2.2-3.6g/L.　Coagulation method: 2.0-4.0g/L.

Clinical significance

1.Increase: (1) Physiology: elderly people, late pregnancy, people taking estrogen preparations orally, after exercise, etc. (2) Acquired: pregnancy intoxication, infectious disease, malignant tumor, cerebral infarction, myocardial infarction, surgery, collagen disease, diabetes, nephrotic syndrome, long-term or large-scale infusion of blood preparations containing fibrinogen (AHG anti-human ball Protein preparations, fresh frozen plasma) and so on.　

2. Reduction: (1) Physiological: newborns.(2) Congenital: ①No fibrinogenemia.②Hypofibrinogenemia.③Part of abnormal fibrinogenemia. (3) Acquired:①Disorders of production: chronic hepatitis, cirrhosis.②Increased consumption: disseminated intravascular coagulation (DIC), thrombosis, hemorrhage, use of snake venom preparations, etc.③Hyperfibrinolysis: shock (electric shock), surgery (primary fibrinolysis), DIC (secondary fibrinolysis), etc.

Precautions

(1) Blood is drawn and fasted for 12 hours, and fresh blood is taken for examination. (2) Oral contraceptives can increase fibrinogen. (3) Women's menstrual period, pregnancy period, and fibrinogen can also increase.(4) The sudden increase of fibrinogen often indicates the possibility of tumor metastasis.

Related diseases

Lower limb venous thrombosis, pediatric hyperviscosity syndrome, malignant atrophic papulosis, thromboangiitis obliterans, diabetic heart disease in the elderly, pediatric meningococcal adrenal syndrome, amniotic fluid embolism, myocardial infarction, malignant ethmoid sinus Tumor, diffuse intravascular coagulation

Related symptoms

Ascites, chest pain, diabetes, nose bleeding, proteinuria