Nomenclature of Clotting factors

Clotting factors are procoagulant substances contained in plasma.

They were officially named in Roman numerals in the order in which they were discovered.

Clotting factor number: I

Clotting factor name: Fibrinogen

Function: Clot formation

Clotting factor number: II

Clotting factor name: Prothrombin

Function: Activation of I, V, VII, VIII, XI, XIII, protein C, platelets

Clotting factor number: III

Clotting factor name: Tissue factor（TF）

Function: Co factor of VIIa

Clotting factor number: IV

Clotting factor name: Calcium

Function: Facilitates coagulation factor binding to phospholipids

Clotting factor number: V

Clotting factor name: Proacclerin, labile factor

Function: Co-factor of X-prothrombinase complex

Clotting factor number: VI

Clotting factor name: Unassigned

Function: /

Clotting factor number: VII

Clotting factor name: Stable factor, proconvertin

Function: Activates factors IX, X

Clotting factor number: VIII

Clotting factor name: Antihaemophilic factor A

Function: Co-factor of IX-tenase complex

Clotting factor number: IX

Clotting factor name: Antihaemophilic factor B or Christmas factor

Function: Activates X: Forms tenase complex with factor VIII

Clotting factor number: X

Clotting factor name: Stuart-Prower factor

Function: Prothrombinase complex with factor V: Activates factor II

Clotting factor number: XI

Clotting factor name: Plasma thromboplastin antecedent

Function: Activates factor IX

Clotting factor number: XII

Clotting factor name: Hageman factor

Function: Activates factor XI, VII and prekallikrein

Clotting factor number: XIII

Clotting factor name: Fibrin-stabilising factor

Function: Crosslinks fibrin

Clotting factor number: XIV

Clotting factor name: Prekallikerin (F Fletcher)

Function: Serine protease zymogen

Clotting factor number: XV

Clotting factor name: High molecular weight kininogen- (F Fitzgerald)

Function: Co factor

Clotting factor number: XVI

Clotting factor name: Von Willebrand factor

Function: Binds to VIII, mediates platelet adhesion

Clotting factor number: XVII

Clotting factor name: Antithrombin III

Function: Inhibits IIa, Xa, and other proteases

Clotting factor number: XVIII

Clotting factor name: Heparin cofactor II

Function: Inhibits IIa

Clotting factor number: XIX

Clotting factor name: Protein C

Function: Inactivates Va and VIIIa

Clotting factor number: XX

Clotting factor name: Protein S

Function: Cofactor for activated protein C