CUSTOMIZED LOGISTICS SOLUTIONS FOR iPSC-DERIVED HEPATOCYTES FROM FRANCE TO CANADA

Shipping hepatocytes using a Cellbox Flight.

PROJECT

A France-based biomedical company required a secure and dependable solution for the transatlantic transport of their very fragile engineered iPSC-derived hepatocytes to Canada.

Owing to their sensitive nature, transporting these cells was not feasible using conventional methods such as cryopreservation

or similar. They would have to be kept at the optimal incubation conditions of 37°C and 5% CO2 during the transport. As part of the

mission to proffer solutions to customer needs, time:matters collaborated with Cellbox Solutions, using their innovative active portable CO2 incubator to ensure strict temperature and CO2 conditions during the entire transport.

TRANSPORT SOLUTION

Living cells must be transported as sensitively and safely as possible. To ensure optimum safety, the cells

were transported to their destination by On Board Courier. The handling of the sensitive cells must be particularly careful - challenging due to customs, security and the permanent monitoring of the box data. time:matters presented the hand carry option as the solution to deliver the cells in less than 24h and with a hypercare approach. All critical milestones like pickup, security checks, flight and customs cleared were tracked by the courier along with the critical vitals of the Cellbox. With the incubator always in sight the courier hand-carried the important cells and was always able to take actions if needed.

RESULT

Within 16 hours the iPSC-derived hepatocytes living cells made their way from France to Canada.The lab confirmed the successful transport - 91% viability of cells in the batch transported vs. 96% for the batch kept in France.