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Cologuard: the first and only FDA approved stool DNA noninvasive colorectal cancer screening test

Exact Sciences
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How does Cologuard work?

Every day the lining of your colon naturally sheds cells. If you have cancer or precancer in your colon, abnormal cells shed into the colon – along with normal cells – where they are picked up by stool as it passes through.

Cologuard uses advanced stool DNA technology to find elevated levels of altered DNA and/or hemoglobin in these abnormal cells, which could be associated with cancer or precancer.

How is a sample collected?

The Cologuard Collection Kit is easy to use, and it’s shipped directly to your home. You collect a single stool sample using this kit, then send it to Exact Sciences Labs via prepaid UPS shipping or pick-up. We provide the result back to your doctor, who will contact you to discuss next steps.

What are the risks and precautions associated with Cologuard?

Cologuard is not for everyone. It is not a replacement for diagnostic or surveillance colonoscopy in high-risk individuals. It may not be right for you if:

You have a personal history of colon cancer, polyps, or other related cancers

You have a family history of colon cancer

You have had a positive result for another screening method in the last six months

You have been diagnosed with a condition that places you at high risk for colon cancer. These include but are not limited to: Inflammatory Bowel Disease, Chronic ulcerative colitis, Crohn’s disease, Familial adenomatous polyposis

You have been diagnosed with a relevant cancer syndrome passed on from your family, such as Hereditary non-polyposis colorectal cancer syndrome, Peutz-Jeghers Syndrome, MYH-Associated Polyposis, Gardner’s syndrome, Turcot’s (or Crail’s) syndrome, Cowden’s syndrome, Juvenile Polyposis, Cronkhite-Canada syndrome, Neurofibromatosis, or Familial Hyperplastic Polyposis

Results should be interpreted with caution for individuals over age 75, as the rate of false positives increases with age

Cologuard may produce false positive or false negative results.

A false positive occurs when Cologuard produces a positive result, even though a colonoscopy will not find cancer or precancer. Any positive result should be followed by diagnostic colonoscopy.

A false negative occurs when Cologuard does not detect colon cancer or precancer even when a colonoscopy identifies the positive result. Following a negative result, patients should continue participating in a screening program at an interval and with a method appropriate for the individual patient.

Cologuard: the first and only FDA approved stool DNA noninvasive colorectal cancer screening test