HORIBA Medical adds extra pre-analytical functionality to its fully automated hemostasis analyzer Yumizen G800

New Software Version 2.36 for HORIBA’s Yumizen G800 Hemostasis Analyzer Enables Automatic Tube Filling Level Checking

HORIBA Medical has introduced more pre-analytical functionality to its Yumizen G800 hemostasis analyzer with the launch of its latest software version 2.36. It is well recognised that pre-analytical conditions are critical in hemostasis and generate up to 70% of the Hemostasis results errors in a laboratory.*1*2 The new Tube Filling Level Check option for the Yumizen G800 helps to overcome a significant pre-analytical error risk factor.

The correct filling of the sample tube is one of the most sensitive pre-analytical parameters in blood coagulation analysis. If filled inaccurately, this will have a direct impact on results accuracy as it changes the ratio of anti-coagulant (normally 1 : 9). Therefore, the tube filling tolerance is clearly indicated on a sample tube to support manual operator checking.

In case of incorrect manual checking of tube fill volume, the new Yumizen G800 software version 2.36 now integrates an optional automatic check of tube filling (using a level detection sensor) that triggers an alarm in the incidence of level abnormality which will directly affect final results.

An insufficient fill volume greatly modifies the fixed blood-to-anticoagulant ratio and increases the dilution of the sample due to the volume of liquid anticoagulant. This may increase the clotting time due to the excess calcium-binding citrate present. It has been reported in literature that when tubes are drawn at less than 89% of total fill, a clinically significant bias exists in test results for APTT, less than 78% for fibrinogen, and less than 67% for coagulation factor VIII.*2

References:

*1: Lippi G, Banfi G, Buttarello M et al. Recommendations for detection and management of unsuitable samples in clinical laboratories. Clin Chem Lab Med. 2007 ; 45(6):728-736.

*2: Lippi G, Salvagno GL, Montagnana M, Lima-Oliveira G, Guidi GC, Favaloro EJ. Quality standards for sample collection in coagulation testing. Semin Thromb Hemost. 2012;38:565–75.