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Crosslinking is essential

Synoz ONE

Cross-linking is essential to the persistence of HA in the tissues. Naturally occurring HA, free HA, floats free in solution, is not crosslinked, and has a half-life of only 1 to 2 days. HA manufacturers crosslink the molecules to form a viscous gel that is more resistant to degradation.

These gels provide a more complex chemical structure and more robust physical barrier to the enzymatic and free radical breakdown in the phagocytes. The crosslinking materials currently in use are; 1,4-butanediol diglycidal ether (BDDE), di-vinyl sulfone (DVS), and p-phenylene bisethyl carbodi-imide (BCDI).

Evaluated the difference between a hyaluronic acid network crosslinked with DVS or crosslinked with BDDE. DVS has a molecular mass (MW = 118) smaller than the BDDE (MW = 202), about half. This fact involves a different behaviour in the cross-linking of the same hyaluronic acid. A smaller mass in fact leads to crosslinking with the formation of slim, smaller, and more stable lattices than a larger mesh bulking agent and, above all, with a prolonged stereometry.

State of art production


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