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Strategies for characterizing size and concentration of viral and non-viral vectors

Live webinar 05 April 2022

Appropriate analytical methods are needed to develop next generation vaccines and advanced medical products based on nanodelivery systems, such as recombinant adeno associated viruses (rAAV) and mRNA loaded lipid-based nanoparticles (mRNA-LNPs).

The average diameter and size distribution are some of the most measured attributes during the development of delivery vectors. These data are used for characterization and stability analysis starting from early development stages through process and formulation development all the way to process control, and batch release for clinical trials and marketed products. Particle concentration is a less used attribute, but can be very beneficial during design, formulation and processing of these delivery vectors, as it helps in monitoring yield and informing dosing.

Selection of the most suitable technology to monitor samples will ultimately depend on the specific properties of drug delivery vectors, on their size and polydispersity, as well as what stage of the development process the measurements take place and what is the purpose of the measurement.

Join us as we take a deep dive into particle sizing techniques and look at several common techniques for determining size distribution and concentration such as:

dynamic light scattering (DLS)

nanoparticle tracking analysis (NTA)

size exclusion chromatography together with static light scattering (SEC-LS)

multi-angle dynamic light scattering (MADLS)

asymmetrical field flow fractionation (AF4)

You can register for free to all our webinars and you will automatically receive the On-Demand version

Details

  • Malvern WR14 1XZ, UK
  • Malvern Panalytical