HRD score Analysis solution

Nanodigmbio Solution

Homologous recombination repair (HRR) is an important pathway for normal cells to repair DNA damage. The loss-of-function variants in BRCA1/BRCA2 may directly result in Homologous Recombination Deficiency (HRD). Meanwhile, the mutation occurred in PALB2, CDK12, RAD51 and other HRR-related genes, as well as other unknown reason, may also lead to HRD. Generally, the detectable genomic aberrations caused by HRD are called "Genomic Scars", including loss of heterozygosity (LOH), large scale state transition (LST) and telomeric allelic imbalance (TAI) [1-2]. These signatures may act as biomarkers for the state of DNA repair deficiency.

Click to find our Nanodigmbio HRD score Analysis solution