#Product Trends
Programmable pumps offer precise and translatable delivery of compounds to stress-free animals
Where do accuracy and animal welfare meet in drug preclinical delivery technology?
Schnell et al. [8] described the impact of restraint, handling, drug dosing and training on baseline physiological cardiovascular parameters. Perhaps more importantly, they showed a significant influence on drug effects. One example was that animal restraint had a 30-fold influence on the Angiotensin II antagonist hypotensive profile-
• IC50 in restraint marmosets: 0.3 mg/kg
• IC50 in unrestraint marmosets: 8 mg/kg
Factor ~ 30
