Sample System, MALDI Obtain High-res Images

Shimadzu Scientific Instruments’ iMLayer matrix vapor automated sample treatment (matrix deposition) system provides a precise, high-resolution method for high spatial resolution imaging mass spectrometry.

Used in conjunction with the company’s MALDI-TOF mass spectrometers, the system uses vaporization to deposit matrix to tissue slices using what is called the “dry coat” method. In this method, matrix powder is heated under vacuum to the boiling point of the matrix crystals. The sample positioned above the matrix then becomes coated with a thin layer of matrix. A laser positioned above the sample is utilized to control the thickness of the matrix layer, resulting in reproducible matrix deposition. Utilizing the dry coat method provides for creation of finer matrix crystal grains as well as improved reproducibility of matrix coatings via automatic coating thickness control. In addition, the sample treatment system features simple touch-panel operation with pre-programmed methods for commonly used matrices. Combining the system with the high-performance MALDI-7090 results in a powerful and user-friendly imaging platform for obtaining high-resolution images.