Heat Therapy Alters Thermoregulation and Behavior in Rats with HFpEF

Does Heat Therapy Help Restore Functional Sympatholysis?

Skeletal muscle contractions depend on a precise neurovascular response that ensures oxygen delivery meets metabolic demand. A critical process, known as functional sympatholysis—the attenuation of sympathetic vasoconstriction during exercise—supports blood pressure regulation and exercise tolerance. When this mechanism is impaired, oxygen delivery to muscles is reduced, a problem observed in individuals with heart failure with preserved ejection fraction (HFpEF). HFpEF is characterized by severe exercise intolerance and limited treatment options, making functional sympatholysis a key target for research and therapy.

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fig 2 from the article

fig2 shows the core body temperature from week 6.

fig 6 from the article

fig 6 showing core body temperature and activity as AvgEA

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