In vitro simulation journey of coil embolic materials before listing

Model:Circle of Willis with Aneurysms ( SJ004D)

Coil embolic materials play an important role in the medical field, especially in vascular embolization therapy. The material can be precisely placed in the blood vessel to block or slow blood flow, thereby achieving the purpose of treatment. However, before it is officially listed and applied to patients, the coil embolic material must undergo rigorous testing and evaluation to ensure its safety, effectiveness and reliability. In vitro simulation plays a vital role in this process.

In vitro simulation is required before coil embolization is listed, for the following reasons:

1. Safety assessment

In vitro simulation allows researchers to test the performance of materials under conditions close to actual physiological conditions to assess their possible risks. For example, blood flow velocity and pressure can be simulated to observe the stability and reliability of the material under these conditions. In addition, the long-term placement of the material in the blood vessel can be simulated to assess the biocompatibility issues and long-term safety that may be caused.

2. Effectiveness verification

In vitro simulation experiments can simulate the process of vascular embolization therapy and verify whether the coil embolic material can effectively block or slow blood flow. By comparing the performance of different materials and designs, researchers can select the best design to improve the success rate of treatment.

3. Quality Control

In vitro simulation experiments provide a standardized test method for evaluating the performance of coil embolic materials produced from different batches or different manufacturers. This helps ensure the consistency and reliability of product quality and reduce variability in the production process.

4. Optimize product design

Through in vitro simulation experiments, researchers can understand the performance characteristics of materials under specific conditions and optimize product design based on these characteristics. For example, parameters such as size, shape, and elasticity of the material can be adjusted according to changes in blood flow rate and pressure to improve its effectiveness in practical applications.

5. Reduce clinical trial risks

In vitro simulation experiments predict the performance of materials in the human body to a certain extent, thereby reducing uncertainty and risks in clinical trials. This helps protect patient safety and reduce the failure rate of clinical trials.