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What are the 4 steps of coagulation?
coagulation, thrombosis
The major steps of blood coagulation include platelet aggregation, thrombin cleavage, reticulin formation and contraction.
When a blood vessel ruptures, platelets quickly gather at the wound to form a platelet plug to slow blood loss. On this basis, thrombin is formed in the plasma, which cleaves lectin to generate activated coagulation factors. The activated coagulation factors then react with reticulated fibrin to form a blood clot, securing the platelet plug to the wound. Finally, the blood clot will be contracted by the muscle fiber cells, enhancing the hemostatic effect.