MEMBRAPURE

ARACUS

THE AMINO ACID ANALYSER ARACUS BASED ON A MODULAR CONCEPT IS THE IDEAL INSTRUMENT FOR THE ANALYSIS OF AMINO ACIDS IN RESEARCH, QUALITY CONTROL AND IN THE CLINICAL LABORATORY.

It combines innovative technologies with the classic routine analysis of amino acids by post-column derivatisation with ninhydrin.

In day-to-day use this produces results with the highest precision, reproducibility and accuracy.

The set-up of the instrument allows the continuous analysis of 96 samples (2 x48 vials). The samples are stored in the cooled autosampler and are injected without sample loss.

A washing routine of the injection valve and syringe pump guarantees zero cross-contamination. The ARACUS instrument is also available with a manual injection system.

The eluent rack contains 6 glass bottles. The fluid volume of each bottle is actively monitored during operation. Eluents, ninhydrin and washing reagent are selectively chosen through buffer selection valves and degassed in micro-vacuum chambers.

The innovative technology of the pump allows the simultaneous operation of two fluid lines (eluent side and reagent side), which guarantees constant mixing.

The maintenance-free LED photometers detect the separated amino acids at 570 nm and 440 nm and the signals are registered by the software aminoPeak.

PHYSIOLOGICAL AMINO ACIDS - Analysis of free amino acids in biological and medical applications (serum, plasma, urine, culture media) or food.

PROTEINOGENIC AMINO ACIDS - Analysis of proteins, peptides, feedstuff or nutrition after hydrolysis.

SPECIFIC AMINO ACIDS - MSUD is a example of a specific application with a dedicated short run programm.

INNOVATIVE CHEMISTRY

The concept behind the ready-to-use eluent and reagent kits allows the reproducible analysis of amino acid samples. Each kit is produced under standardised procedures, tested and certified before shipping. Depending on the application, the eluent and reagent kit contains the necessary amount for 500 or 1,000 analysis runs. No inert gas is necessary for the eluents due to our innovative formulation.

OPERATION CONTROL

ARACUS is operated with the user friendly, self-explanatory software iControl. Implemented, optimised separation programmes are correlated with each sample for the analysis. Data analysis, reintegration and chromatogram view of previous samples can be done while the instrument is analysing a sample.

The current status of important instrument parameters is shown as well as the fluid volumes of each eluent and reagent bottle. Different alarm levels inform the operator as soon as a minimum value is reached. All operational parameters and events of each analysis are documented in a log file.

DATA ACQUISITION AND HANDLING

The data acquisition and analysis software aminoPeak records two analogue channels simultaneously (570 nm, 440 nm). Chromatograms are shown online. Internal databases allow fast peak identification. Quantitative calculations are performed with internal or external standards, dilution and/or multiplication factors.

Several analysis runs can be compared using compiler programmes. The results of each analysis are documented in an individual report. As an option, Clarity can be used if 21 CFR Part 11 conformity is required.