#Industry News
Continuous In‑Body Monitoring Uncovers Physiological Signatures of Pertussis
Reduced daytime activity and altered circadian temperature pattersn
A new mSphere study from FDA and CDC scientists compared three pertactin‑negative (PRN‑negative) Bordetella pertussis strains with a pertactin‑positive reference strain using the baboon infection model. As PRN‑negative variants have become increasingly common in countries using acellular pertussis vaccines, the team examined whether these strains differ in disease potential. All strains colonized the airway similarly, but they produced noticeably different levels of disease severity — showing that circulating PRN‑negative strains are not clinically uniform.
