Top-seller Product introduction (CDKN1A and Bcl-2 )

Research tools for monoclonal rabbit antibodies

Background:

CDKN1A is a member of cyclin-dependent kinase inhibitors, and known as a regulator of cell cycle progression and inflammatory processes. Dysfunction of the CDKN1A (p21) correlates strongly with TP53 structural abnormalities, and mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. Further studies revealed that CDKN1A has much boarder range of biology functions, from the regulation of transcription, DNA repair, cell motility, apoptosis, to stress response, control of cell differentiation and replicative senescence. It also has been described as a suppressor of autoimmunity in various diseases such as lupus nephritis, rheumatoid arthritis and autoimmune pancreatitis.

Bcl-2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes, and is shown to promote tumorigenesis by inhibiting cell death rather than by promoting cell-cycle progression. Even though this target has been studied for decades, and the field of Bcl-2 research is regarded by many as mature now. New discoveries can still amaze us with the intriguing features of the Bcl-2 protein. As it has been proved that Bcl-2 can directly and indirectly active BAX and BAK, which are the proteins cause mitochondrial membrane permeabilization (MOMP) and function as pro-apoptosis factor, Bcl-2 has been found also have pro-survival function that inhibits apoptosis by removing BAX and BAK from mitochondrial membrane.