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Featured Research Tools for Lipid Metabolism in Cancer
Research tools for monoclonal rabbit antibodies
Fatty acids (FAs) are the main building blocks of different lipid species, contribute to the vast structural diversity of the cells and serve as the secondary messengers in signaling pathways of biochemical processes. In cancer cells, FAs are obtained mainly by two methods, exogenous uptake and synthesis. In terms of exogenous FA uptake, specialized transporters are required to facilitate efficient movement across the plasma membrane, and the most well characterized of these include CD36, SCL27 and FABPs. As for the synthesis, the regulation mainly occur at transcriptional level through the activation of SREBPs and induce the transcription of enzymes such as ACC, ACLY and FASN.
