#Product Trends
Featured Research Tools for Regulatory Signaling Pathways in Cancer Metabolism
Research tools for monoclonal rabbit antibodies
As for the studies about anabolism in tumor growth, two main questions need to be answered: first is, what are the rate-limiting macromolecules during synthesis, and second, which are the pathways that participate in the process. From the researches published in these few years, we can see the field has expanded from central carbon pathways such as glycolysis and TCA cycle to the branch metabolic pathways that are needed for tumor growth, progression, and metastasis. Some of the results published in recent studies might partially answer the aforementioned questions. Signaling pathways such as ERK and AMPK play crucial roles in the anabolism of tumor growth, since it has been proved that activation of ERK signaling pathway can promote purine synthesis for tumor growth and the loss of AMPK activity has a similar function. Moreover, the hyperactivation of MYC and mTORC1 could be seen as a new therapeutic intervention for the metabolic vulnerabilities of cancer cells.
