Background: Gastrointestinal Stromal Tumors (GISTs) are gastrointestinal mesenchymal tumors that commonly originate from the digestive tract. They are characterized by their morphology and typically show positivity for CD117 (c-kit). The activation mutations of the KIT or PDGFRA genes are the main drivers of GIST development. GISTs are most commonly found in the stomach ...
The CLDN protein family consists of at least 27 transmembrane proteins, which can be classified into two types: classical and non-classical, based on their sequence. CLDN18 belongs to the non-classical type. The protein expressed by CLDN18 undergoes splice modifications, resulting in two subtypes: CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective marker protein that ...
On May 25, 2023, ASCO's official website released some abstracts of this conference. In this issue, we will explore the new developments in lung cancer immunotherapy presented at the ASCO conference. Pembrolizumab and ramucirumab as neoadjuvant therapy for PD-L1-positive stage IB-IIIA lung cancer (EAST ENERGY). Abstract Number: 8509 Title: Pembrolizumab and ramucirumab ...
1. Overall survival (OS) Overall survival was defined as the time from randomization (or start of treatment in single-arm trials) to death from any cause. OS is relatively objective and precisely measurable, and it is the most reliable end point for measuring the clinical benefit of anticancer drugs in randomized controlled clinical trials. Advantages: It is widely used ...
Globally, it ranks as the eighth most common malignant tumor among women and is the most deadly gynecologic malignancy, with the highest mortality rate among the three major gynecologic tumors (ovarian, cervical, and endometrial cancers) [1]. In China, the situation regarding the prevention and treatment of ovarian cancer is equally grim. Ovarian cancer ranks third among...
According to statistics from the World Health Organization, lung cancer is the leading cause of cancer deaths worldwide, with an incidence rate of 11.4% and a mortality rate of 18.0%. In China, lung cancer has the highest incidence rate among malignant tumors. Lung adenocarcinoma (LUAD) is the most common histological subtype of non-small cell lung cancer (NSCLC), accoun...
In 2014, the first PARP inhibitor Olaparib (Olaparib) was launched. This is the first marketed drug under the concept of Synthetic Lethality, which opened up a new path for tumor-targeted therapy. PARP inhibitors and their mechanism The full name of PARP inhibitors is polyadenosine diphosphate ribose polymerase inhibitors. In 1922, Calvin Bridges, a geneticist working ...
According to the report, "BRAF mutation test", "EGFR mutation test", "KRAS mutation test" and "KRAS mutation test" participated by Xiamen Spaceseq Medical Testing Laboratory Co. (hereinafter referred to as "Sapceseq Medical Laboratory") passed the 7 inter-laboratory quality assessment projects, including "BRAF mutation test", "EGFR mutation test", "KRAS mutation test" an...
Abstract Ovarian endometrioid (ENOC) is one of the important subtypes of ovarian cancer, accounting for 10-15.8%, which is related to endometriosis and Lynch syndrome. The morphological heterogeneity of ENOC is high, and the prognosis is also different. ENOC and endometrioid carcinoma (EEC) have many similarities in molecular characteristics and histology. The applicatio...
Background RECIST (The Response Evaluation Criteria In Solid Tumors) is a set of definitions for assessing the effectiveness, stability, or ineffectiveness of tumor treatment. This guideline mainly introduces the standardized method of objectively evaluating the changes in tumor size in clinical trials of solid tumors in adults and children. The first tumor response cri...
Background Malignant pleural effusion (MPE), also known as pleural effusion, is a pleural effusion caused by the metastasis of malignant tumors originating in the pleura or other malignant tumors involving the pleura. Almost all malignant tumors can invade the pleura and produce MPE, which is more common in lung cancer, breast cancer, gastrointestinal cancer and other ca...
Neoadjuvant immunotherapy for lung cancer mainly refers to the use of immune checkpoint inhibitors (ICIs) to eliminate the immune suppression of tumor cells on T cells by blocking immune checkpoint molecules such as PD-1/PD-L1/CTLA-4, and thereby reactivating T cells to clear tumor cells [2]. Currently, clinical research on neoadjuvant immunotherapy for Non-small cell lu...
Background Introduction Lung cancer is the most common cancer in the field of tumors, and it is also the malignant tumor with the highest morbidity and mortality in the world. The most common type of lung cancer is non-small cell lung cancer (NSCLC), accounting for 80% to 85% of all lung cancers. Due to its low degree of malignancy, the growth and division of cancer cell...
01/ Worldwide gastric cancer Stomach cancer Stomach cancer remains an important cancer worldwide and is responsible for over one million new cases in 2020 and an estimated 769,000 deaths (equating to one in every 13 deaths globally), ranking fifth for incidence and fourth for mortality globally Rates are 2-fold higher in men than in women. In men, it is the most commo...
The report shows that SpaceGen examination results are completely consistent with the official CAP results, and passed the CAP Inter-laboratory Quality Assessment with a perfect score. It has once again proved that SpaceGen has the ability to provide high-quality tumor clinical testing services, and the level of genetic testing has reached the international advanced leve...
01 Bladder Cancer Overview Bladder cancer is one of the most common malignant tumors of the urinary system., the incidence of bladder cancer ranks 9th among malignant tumors worldwide; according to the data released by the National Cancer Registration Center in 2019: the incidence of bladder cancer in China in 2015 was 5.80/100,000, ranking 13th among systemic malignant...
Pharmacogenomics Pharmacogenomics is a discipline that studies the relationship between genetic variations and drug responses, with the goal of improving drug efficacy and safety. It investigates the genetic characteristics that affect individual differences in drug absorption, distribution, metabolism, and elimination, as well as the different responses to drugs caused ...
In 2020, there will be approximately 19.3 million new cancer cases worldwide, including 1.8 million new cancer cases in the United States alone. KRAS gene mutations are found in approximately one in seven human cancers, and the KRAS gene has become one of the major oncogenic drivers of human cancer [1]. KRAS-Kirsten rats arcomaviral oncogene homolog The RAS protein is a...
Introduction: Professor Wu Yilong- Guangdong Provincial People's Hospital and Guangdong Lung Cancer Institute pointed out that the three key words in the field of lung cancer in 2022 are: minimal residual disease (MRD), CheckMate816 and KRAS. Today,let us talk about CheckMate816 research. For Opdivo, 2022 is destined to be an extraordinary year, the Nivolumab and plati...
NMPA Approval March 21, 2022 Ensartinib (first-line treatment for lung cancer) On March 21, 2022, Betta Pharmaceuticals Co., Ltd. received the "Drug Registration Certificate" issued by the State Drug Administration (drug approval number: GUO XIE ZHU ZHUN H20200009, GUO YAO ZHUN ZI H20200010), Ensartinib. hydrochloride capsule has been approved for marketing as a new in...
What is a liquid biopsy? In the 10 Breakthrough Technologies 2015 list published by MIT Technology Review magazine, liquid biopsy technology was honoured on the list. ▲Comparison of traditional biopsy and liquid biopsy Liquid biopsy refers to the analysis and diagnosis of cancer and other diseases by testing blood or other body fluids such as urine, saliva, pleural ef...
