This work marks a major step toward providing cancer researchers with a new tool for tracking tumor progression and physicians new technology for tissue pathology and diagnostics. Typically, the process for diagnosing cancer takes several days. A surgeon first removes a tissue sample that is then processed with chemical dyes; later, the sample is sent to a pathologist fo...
According to a Stanford News article, the discovery of the enzyme, called SETD3, solves a 50-year-old mystery of how and why a specific modification (often observed after exercise) to a protein in muscles occurs. The study was published in Nature. The protein, SETD3, adds a molecule called a methyl group to a certain location on a protein — actin — found in muscle ...
A Japanese drug company is offering up a big claim: Shionogi & Co. says it has an experimental pill that can kill the flu virus within a single day, according to news reports. In a clinical trial, a single dose of the drug made by the pharmaceutical company eliminated the virus from people's bodies in a median time of 24 hours, The Wall Street Journal reported. Both J...
AAP-300 Heavy Metals Analyzer is composed of main unit, Colorimeter cell components, colorimetric tube components, and it is a small-sized portable fast measuring apparatus, which features fast measuring speed, small in size, light in weight and easy to carry, making the handheld operation convenient. This apparatus can not only be used under the laboratory environment b...
“Although there are many ways to detect metastasis once it has occurred, there has been nothing available to ‘see’ or ‘measure’ the potential of a tumor cell to metastasize in the future,” said Pradipta Ghosh, MD, UC San Diego School of Medicine professor and director of the university’s Center for Network Medicine and senior author of a new study appearing in journal iS...
Ian Johnson, Bioquell’s Executive Chairman, commented: “Bioquell can be proud of setting another milestone with the production of the 200th Bioquell Qube aseptic workstation. In fact, I am delighted to report that we have seen a 90% increase in sales of the popular isolator system compared to the same period last year.“ Bioquell’s Qube aseptic workstation incorporates...
Development of severe disease is associated with a progressively augmented imbalance in pro- and anti-inflammatory responses to high parasite loads and sequestration of parasitized erythrocytes. Although these phenomena collectively constitute common denominators for the wide variety of discrete severe malaria manifestations, the mechanistic rationales behind discrepanci...
African Americans (AAs) have a 2–3-fold higher prevalence of monoclonal gammopathy of undetermined significance (MGUS) and a similarly higher incidence of MM, along with approximately 4-year younger age of onset compared to European Americans (EAs). An international team of scientists led by those at the Mayo Clinic (Rochester, MN, USA) performed cytogenetic analyses,...
The disease is spread from human to human is through contact with blood and/or bodily fluids (urine, saliva, feces, vomit, sweat, breast milk and semen) of infected individuals. This may be through direct contact and/or droplet spread (droplets of infected bodily fluids produced by sneezing, coughing or talking) or via objects (such as needles) and environments that have...
After menopause, women enter post-menopause, when they are more vulnerable to heart disease and osteoporosis. It is important for women to understand their stage of menopausal transition to learn what, if any, additional health risks they may face and any preventative health steps to take. The US Food and Drug Administration (FDA, Silver Springs, MD, USA) has approved...
However, fetuses exposed to Zika in the womb are at risk for devastating neurological defects. One of those defects, microcephaly, a smaller-than-usual head size, gained prominence in 2015 with Brazil reporting an unusual number of cases in babies born to mothers infected with the virus. Scientists from the University of Southern California (Los Angeles, CA, USA) and ...
MxA is an intracellular protein that becomes elevated in the presence of acute viral infection and CRP is a nonspecific inflammatory protein that is elevated in the presence of any clinically significant infection. Thus, unlike a standalone CRP test, MxA confers specificity to the test through the combined interpretation of the results. The FebriDx test (RPS Diagnosti...
Current clinical practice guidelines stipulate with a high level of evidence that biochemical screening for PPGLs should include measurements of plasma free or urinary fractionated metanephrines that is normetanephrine and metanephrine, with no recommendation concerning preference of either test. An international team of scientists led by those at Technische Universit...
Lactate is an intermediary metabolite produced in relatively anaerobic conditions. Measurement of circulating lactate level is useful in assessing tissue perfusion in critically ill patients and in those being suspected of sepsis. It is produced by many cells and circulating levels reflect rate of production and of metabolism by the body. Laboratory scientists at Park...
Point-of-care diagnostic tests, that can often provide results within minutes, are used globally as hospitals face increased pressures to address overcrowding in emergency rooms and longer wait times. The goal of with-patient diagnostic tests is to deliver results with accuracy similar to the gold standard of high-sensitivity laboratory tests. A team of scientists col...
C-reactive protein (CRP) is an immune system response to toxins or injuries in systemic inflammation, while CRP levels increase with age. Although multiple AD-related genes are associated with the level of CRP, the association between blood CRP levels and risk of AD are not conclusive as previous studies have presented both low and high levels of CRP in patients with AD....
Leigh syndrome has historically had a high mortality rate in childhood or adolescence. Over 90 different genes necessary for mitochondria to function properly are now known to cause it, with disease-causing gene variants rooted in DNA, either within a cell's nucleus or in the separate mitochondrial genome. A large team of scientists led by those at the Children's Hosp...
The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenging because of the complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Scientists at the Oregon Health & Science University (Portland, OR, USA) used exome sequencing, RNA sequencing, and/or ex vivo drug s...
Multiple companies have developed MSI assays to detect a variety of early-stage cancers. The US Food and Drug Administration (FDA Silver Springs, MD, USA) has granted Breakthrough Device designation to two companies for their existing next-generation sequencing RUO liquid biopsy assays to include MSI detection. Under the program, the FDA works with a test developer to re...
Now, in new research, scientists at the Lewis Katz School of Medicine at Temple University (LKSOM) show that this limitation may be overcome by targeting liver kinase B1 (LKB1) protein. In mice with spinal cord injury, targeted LKB1 upregulation stimulated long-distance neuron regeneration, leading to gains in functional recovery. "Our investigation shows that LKB1 is...
In the United States, antibiotic resistance causes over 2 million illnesses and 23,000 deaths each year. The World Health Organization (WHO) surveyed half a million people and found that the five most common drug-resistant bacteria are: Escherichia coli Klebsiella pneumoniae Staphylococcus aureus Streptococcus pneumoniae Salmonella With the exception of S. pne...
Popping the top on house paint usually draws people to look inside the can. But Princeton researchers have turned their gaze upward, to the underside of the lid, where it turns out that pattern of droplets could inspire new ways to make microscopically small structures. The trick comes in controlling the droplets, which form under competing influences like gravity and...
The researchers say the approach can be used on other infection-causing pathogens, including staph and bacteria that cause urinary tract infections, pneumonia and meningitis. "Knowing which genes are conferring antibiotic resistance could change the way infectious diseases are treated in the future," said co-senior author Jonathan Monk, research scientist in the Depar...
The discovery holds significant promise for medical and other applications, making it possible for implants such as vascular grafts, replacement heart valves and artificial joints to bond to the body without risk of infection or blood clotting. The new nanotechnology has the potential to greatly reduce false positives and negatives in medical tests by eliminating inte...
Working with their local service partners BEMISS, a solar installation company based in Lomé, Dulas will deliver, install and maintain the vaccine refrigerators across the whole of Togo in the coming months. Togo is one of the world’s poorest countries, with just over 81% of its rural population below the poverty line.[1] The country’s health sector often struggles to...
The IKA Oven 125 control dry and IKA Oven 125 control dry glass with 125 l illuminated interior and up to 6 insertable shelves are powerful drying cabinets for temperature regulation, drying, ageing and heating tasks. The control versions heat up to 300 °C and meet highest security requirements with the integrated temperature limiter (TWB according to DIN 12880). Apart f...
The device was introduced as a world first at the Achema 2018 in Frankfurt and has been officially launched on August 1, 2018. STARVISC has a broad range of applications. This is particularly helpful during product development: STARVISC already clearly indicates while running research programmes as to whether the stirred substance can be used as desired. The device is ch...
The Metrohm Application Note includes the effective determination of ANC for scores of over-the-counter (OTC) antacids. The titration procedure works for samples such as magaldrate and simethicone for oral suspension and alumina, magnesia and simethicone in the form of chewing gums as well as for 36 further samples. Antacids neutralise stomach acidity to relieve heart...
NuAire offers two options for properly heating and maintaining temperature in the growth chamber: direct heat and water jacket configuration. The In-VitroCell NU-5700 and 58700 Direct Heat series use direct heating elements to offer a quick return to the set temperature after the door is opened. The In-VitroCell NU-8600 Water Jacket series uses heated water to surround t...
The SH450 autoclave has an extra-large 450 litre rectangular chamber and is a must for any laboratory undertaking high-volume sterilising procedures. It is also ideal for those labs frequently tasked with handling tall and bulky items. And despite its large chamber and high loading capacity the autoclave requires only a relatively small floor area. In order to strengt...
Astell’s Benchtop range is available in three chamber capacities; 33 litres, 43 litres and 63 litres, and as Classic and ‘Autofill’ versions. Autofill Benchtop autoclaves require no plumbing whatsoever - simply plug the unit in to a single phase power supply and fill the integral water reservoir. Once filled, this provides water for up to 15 cycles by recycling the water...
The compact Mass Flow Controller is equipped with a microprocessor based pc-board with signal and fieldbus conversion and an integrated digital controller for accurate mass flow control by means of the integrated piezoelectric control valve. The flow controller has a very small internal volume, making the Coriolis MFC an ideal device for fast, repetitive dosing and filli...
Memmert introduced two temperature control appliances with climate-neutral CO2 (R744) as the refrigerant. The climate chamber ICHeco and the cooled incubator ICPeco are not only more environmentally friendly, but also more efficient and economical to maintain than appliances cooled with fluorinated greenhouse gases. With the gradual phasing out of synthetic refrigerants,...
It combines the advantages of data acquisition from below with the established merits of 3D confocal Raman imaging, a powerful and versatile technique that can chemically characterise samples nondestructively and without labeling or other specialised preparation. The speed, sensitivity and resolution of the WITec alpha300 series are now available from a new angle. Resea...
Inverted metallurgical microscopes observe samples from underneath, enabling the user to inspect thick or heavy samples without adjusting the orientation of the sample surface. This ability makes the GX53 microscope a practical tool for viewing the microstructure of metals used in automotive and other manufactured metal components. With the incorporation of MIX observ...
Bench space is used efficiently due to the LA-350’s compact size (297 mm x 420 mm). The compact size preserves bench space and makes it possible to transport the instrument to different locations within a facility or ship to remote locations for on-site testing where it is not practical to purchase an additional analyser. The clever design and precision, high quality man...
