Shanghai TOW Intelligent Technology company News and Trends items

Sleep Deprivation System for Laboratory Animals The Sleep Deprivation System is a device commonly used to induce sleep deprivation in experimental animals, such as mice and rats. By periodically activating an interference rod to disturb the animals, the system effectively prevents them from entering a sleep state. This system is primarily applied in scientific research ...

Introduction This multi-functional exposure system is specifically designed for laboratory animals, providing a controlled environment to study the effects of various substances on biological organisms. The system integrates both whole-body exposure and inhalation exposure methods, making it adaptable to a wide range of research needs. Here’s an overview of its main feat...

Introduction The diaphragm neuromuscular junction (NMJ) is a critical connection point between the nervous and muscular systems. It is responsible for transmitting signals from the nervous system to the muscles, triggering muscle contraction. Specifically, the functions of the diaphragm NMJ include the following aspects: Signal Transmission When the respiratory center...

Background Antibiotics have been a powerful weapon for humans in the fight against microbial infections. However, the extensive use of antibiotics has led to the emergence of drug-resistant bacteria in recent years. The discovery of host defense peptides (HDPs) has brought hope for combating infections caused by drug-resistant bacteria. However, these natural peptides ar...

Study Introduction Glucocorticoids are crucial for regulating metabolic processes and have significant applications in medical treatments. However, excessive glucocorticoids are known to cause negative metabolic effects, including hyperglycemia, muscle atrophy, and fat accumulation, ultimately leading to Cushing's syndrome. The effects of glucocorticoids on energy metabo...

Background Silkworms are the sole source of natural silk. For thousands of years, silk has held significant cultural, economic, and practical importance in China. In modern times, silk has found widespread applications in medicine, beauty, and industry. Measuring the energy metabolism of silkworms is crucial for optimizing their husbandry management and advancing the s...

Abstract When sleep is altered, the expression of clock genes also changes, indicating that these genes play a role in sleep regulation. For example, keeping animals awake during their normal sleep period affects clock gene expression in peripheral tissues such as the brain cortex, liver, and kidneys. Since clock gene expression responds to changes in feeding and sleep-w...

Abstract Elevated levels of Branched-Chain Amino Acids (BCAAs) are associated with obesity and insulin resistance. However, the long-term effects of a BCAA-rich diet on late-life health and lifespan remain unclear. This study reveals that under a fixed-calorie and equal macronutrient diet, long-term intake of a high BCAA diet leads to overeating, obesity, and a shortene...

Introduction to the Research The abuse of opioid drugs poses a significant threat to economic development, social stability, and public health. Morphine, a commonly used opioid analgesic in clinical practice, is limited in its application due to side effects such as addiction and analgesic tolerance. Opioid addiction is a complex brain disorder, where prolonged and repe...

Background Over the past few decades, the use of sleeping pills has dramatically increased along with the number of people suffering from sleep disorders. Similarly, dependency on these medications has also risen sharply. However, excessive use of sleeping pills can lead to unexpected abnormal behaviors and subsequent metabolic diseases, particularly metabolic disorders...

Background Sleep is a fundamental physiological process essential for maintaining health. However, factors related to modern lifestyles have led to an increase in poor sleep quality or insufficient sleep, resulting in various health problems. Sleep fragmentation (SF), which refers to the disruption of sleep architecture, is commonly observed in conditions such as obstru...

Background Currently, a normobaric hypoxic rat model of pulmonary arterial hypertension has been established domestically, aimed at addressing cor pulmonale resulting from the progression of chronic bronchitis and emphysema. Animal models of chronic high-altitude heart disease induced by pulmonary arterial hypertension are typically developed in decompression hypoxia ch...

Overview of Obesity Obesity is a chronic condition and a key contributor to the development of hypertension, coronary heart disease, stroke, type II diabetes, dyslipidemia, and other chronic illnesses. A significant cause of obesity and metabolic syndrome is the dysregulation of energy metabolism, primarily due to excessive intake of high-energy foods. Research Methods...

Whole Body Plethysmography System-WBP The whole body plethysmography system can measure the respiratory parameters of conscious and freely moving animals, such as respiratory rate, tidal volume, airway hyperresponsiveness (AHR), etc. During the test, the animal can be conscious and unrestrained, avoiding the impact of traumatic tracheotomy and anesthesia, making the exp...

Introduction Asthma is generally considered as a disease with the characteristics of chronic airway inflammation, airway hyper-responsiveness and remodeling. Multiple cells are involved in its onset. Airway epithelium directly contact with allergens and is involved in the onset of the asthma, which is possibly colsely connect to the asthma, chronic airway inflammation, ...

Module composition (Tow-Int Tech - Animal Metabolism Monitoring System) The animal metabolism monitoring system independently developed by Tow-Int Tech is a highly flexible modular platform. Through one software, different functional modules in the cage can be controlled simultaneously, including the respiratory entropy metabolism monitoring module, environmental temper...

Background Metabolic diseases, mainly obesity, affect over 30% of the global population and have become a major public health crisis in the past few decades (Roger et al., 2020). Meanwhile, hypertension also exists in over 30% of the global population, and there is a significant overlap between these two groups (Virani et al., 2021). Although cardiovascular disease rema...

Background Research has confirmed that activating catecholamine neurons in the ventrolateral medulla oblongata (RVLM-CA) under hypoxic conditions can enhance sympathetic nerve output, thereby increasing blood pressure (BP). To explore whether these neurons are also involved in regulating respiratory and cardiovascular variables other than blood pressure, we used the Cre...

Background Air pollution is like a silent killer, causing approximately 3.7 million deaths worldwide each year, accounting for 6.7% of all deaths worldwide. Deaths related to air pollution are mostly caused by respiratory diseases such as lung cancer and respiratory infections. According to the emission rate/formation source of pollutants, air pollutants can be divided ...

Background Ambient temperature is related to our lives and has an important impact on human health. Recent studies have linked changes in environmental temperature to metabolism, gut microbes, and anti-cancer immune responses. Systemic metabolic changes induced by ambient temperature generate antitumor immune responses. Interactions between the gut microbiome and immuno...

Symptoms include shortness of breath (dyspnea), rapid breathing (tachypnea), and bluish skin coloration (cyanosis). For those who survive, a decreased quality of life is common. Hence, It is very important for researchers to study and know more about the mechanism of the disease and develop a newer treatment option for the public, providing a life-saving solution for th...

The Nose-only exposure system is suitable for mice, rats, guinea pigs, and other laboratory animals for nose-only drug delivery. It ensures excellent air-tightness and uniform exposure concentration (Drug-containing aerosols generated from liquid-type test samples, dry-powder samples, nanoparticles, or other test gases). Thus, it is a perfect system setup for NOE experim...